Extracellular vesicles (EVs) are nano-scale carriers of proteins, nucleic acids, and metabolites, playing a vital role in intercellular communication and disease progression. With their unique molecular cargo and clinical relevance, EVs are emerging as promising biomarkers and drug delivery vehicles. However, their heterogeneity poses challenges in isolation and analysis.

Proteonano™ offers a robust solution for high-throughput EV proteomics, enabling efficient protein identification from plasma-derived EVs. Compatible with mainstream EV isolation methods—including ultracentrifugation, PEG precipitation, and immunoaffinity capture—Proteonano™ streamlines your workflow from EV enrichment to deep protein profiling.

Conclusion

This study demonstrates the superior performance of the Proteonano™ Ultraplex Proteomics Platform by Nanomics Biotech in plasma EV proteomics. Compared to commercial kits, Proteonano™ shows:

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1. Enhanced Sensitivity and Coverage: Identifies significantly more EV proteins, including those in the ExoCarta Top 100 and Surface550 datasets, enabling deeper proteomic profiling.

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2. Optimized EV Isolation: Proprietary enrichment technology efficiently captures extracellular vesicles from plasma while minimizing non-target protein interference, resulting in high-purity EV protein samples.

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3. High Reproducibility and Standardization: Integrates automated workflows and rigorous data analysis pipelines to ensure consistent, high-quality results across experiments.

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Together, these advantages position Proteonano™ as a powerful and reliable platform for plasma EV proteomics, supporting advanced biomarker discovery and translational research.

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To learn more, please download the application note.